Botanical Research Portfolio

• Tan, K.K.; Kim, K.H. Alternanthera sessilis Red Ethyl Acetate Fraction Exhibits Antidiabetic Potential in Obese Type 2 Diabetic Rats. Evid.-Based Complement. Altern. Med. 2013, 845172. 
• Bhuyan, B.; et al. Effects of Alternanthera sessilis on Liver Function in Carbon Tetrachloride-Induced Hepatotoxicity in Rats. Indian J. Clin. Biochem. 2018, 33, 190–195. 
• Muniandy, K.; et al. Suppression of Proinflammatory Cytokines and Mediators in LPS-Induced Macrophages by Alternanthera sessilis via NF-κB Pathway Inhibition. J. Immunol. Res. 2018, 3430684. 
• Mohd Razali, N.N.; et al. Protective Effects of Alternanthera sessilis Extract against TNF-α or H₂O₂-Induced Endothelial Activation. Evid.-Based Complement. Altern. Med. 2022, 8738435.

‍

• Park, D.W.; et al. Hepatoprotective Effect of Centella asiatica Extract against Acetaminophen-Induced Liver Injury in Mice. Toxicol. Res. 2020, 37, 261–275. 
• Jeong, Y.J.; et al. A Randomized, Double-Blind, Placebo-Controlled Study on the Efficacy and Safety of Centella asiatica Extract in Subjects with Elevated ALT. Appl. Sci. 2021, 11, 11498. 
• Chang, Y.B.; Ahn, Y.; Seo, D.; et al. Centella asiatica Reduces Body Fat Accumulation via Regulation of Lipid Metabolism in Diet-Induced Obesity Models. Appl. Biol. Chem. 2023, 66, 88. 
• Hong, J.W.; Park, H.Y.; Kim, H.A.; Kim, J.W. Anti-Obesity Effects of Centella asiatica via Inhibition of Adipogenesis-Related Gene Expression. Food Sci. Technol. 2023, 43, e114222.

‍

• Alam, A.; Ferdosh, S.; Ghafoor, K.; Hakim, A.; Juraimi, A.S.; Khatib, A. Clinacanthus nutans: A Review of the Medicinal Uses, Pharmacology and Phytochemistry. Asian Pac. J. Trop. Med. 2016, 9, 402–409. 
• Zulkipli, I.N.; Rajabalaya, R.; Idris, A.; Sulaiman, N.; Kifli, N. Clinacanthus nutans: A Review on Ethnomedicinal Uses, Chemical Constituents and Pharmacological Properties. Pharm. Biol. 2017, 55, 1093–1113. 
• Lin, C.M.; et al. Recent Advancement in Anticancer Activity of Clinacanthus nutans (Burm. f.) Lindau. Evid.-Based Complement. Altern. Med. 2021, 1–12. 
• Chiangchin, S.; et al. Genetic Diversity of Clinacanthus nutans and Its Association with Anti-Apoptotic, Antioxidant, and Antibacterial Activities. Sci. Rep. 2023, 13, 1–12. 

‍

• Qi, R.; Li, X.; Zhang, X.; Huang, Y.; Fei, Q.; Han, Y.; Cai, R.; Gao, Y.; Qi, Y. Ethanol Extract of Elephantopus scaber L. Attenuates Inflammatory Response via Inhibition of NF-κB Signaling by Dampening p65–DNA Binding Activity in Lipopolysaccharide-Activated Macrophages. J. Ethnopharmacol. 2020, 250, 112499.
• Cvetanova, B.; et al. Deoxyelephantopin and Its Derivative DETD-35 Suppress BRAFV600E Mutant Melanoma Lung Metastasis in Mice. Int. J. Mol. Sci. 2021, 22, 1–14. 
• Chen, J.J.; et al. Deoxyelephantopin, a Germacrane-Type Sesquiterpene Lactone from Elephantopus scaber Induces Mitochondrial Apoptosis of Hepatocarcinoma Cells by Targeting Hsp90α In Vitro and In Vivo. Phytother. Res. 2023, 37, 1–12. 
• Wang, C.; Sun, D.; Deng, Q.; Sun, L.; Hu, L.; Fang, Z.; Zhao, J.; Gooneratne, R. Elephantopus scaber Polysaccharides Alleviate Heat Stress-Induced Systemic Inflammation via Modulation of Gut Microbiota and Metabolites. Nutrients. 2024, 16, 262.

‍

• Zawawi, N.; et al. Strobilanthes crispus Leaves Extract Induced Lipolysis and Increased Leptin Level in Diet-Induced Obese Rats Fed a High-Fat Diet. Int. Food Res. J. 2016, 23, 1115–1122. 
• Gordani, N.; et al. Stem Hexane Extract of Strobilanthes crispus Induces Apoptosis in Triple-Negative Breast Cancer Cell Line. Nutr. Cancer. 2021, 73, 1–10. 
• Baraya, Y.S.; et al. Strobilanthes crispus Elicits Anti-Tumor Immunogenicity in In Vitro and In Vivo Metastatic Breast Carcinoma. PLoS ONE. 2022, 17, e0264232.
• Muhammad, S.N.H.; Safuwan, N.A.M.; Yaacob, N.S.; Fauzi, A.N. Regulatory Mechanisms on Anti-Glycolytic and Anti-Metastatic Activities Induced by Strobilanthes crispus in Breast Cancer In Vitro. Pharmaceuticals, 2023, 16, 1–15.

‍

• Adaramoye, O.A.; et al. Lipid-Lowering Effects of Vernonia amygdalina in Rats Fed a High-Cholesterol Diet. Vasc. Health Risk Manag. 2008, 4, 235–241. 
• Ch’ng, Y.S.; et al. Vasorelaxant Properties of Vernonia amygdalina Extract and Its Mechanisms. Pharm. Biol. 2017, 55, 2083–2094. 
• Purwanti, N.; Aditya, R. Effectiveness of Vernonia amygdalina Tea in Reducing Cholesterol Levels in Individuals with Hypercholesterolemia. J. Health Sci. 2021, 14, 1–7. 
• Edo, G.I.; et al. Biological and Bioactive Components of Vernonia amygdalina: Insights into Health and Nutritional Benefits. Food Chem. Adv. 2023, 3, 100488.

‍